Recurrent uveitis in a patient with adult onset cyclic neutropenia associated with increased large granular lymphocytes
نویسندگان
چکیده
منابع مشابه
Adult-onset cyclic neutropenia is associated with increased large granular lymphocytes.
Human cyclic neutropenia occurs in adults as well as children. Clinical illness is similar in the childhood and adult diseases, but distinctly different modes of onset suggest heterogeneity in its pathophysiology. We studied seven patients with cyclic neutropenia, three with disease acquired in adulthood, and four with the childhood-onset disorder. All three patients with adult-onset cyclic neu...
متن کاملAdult-onset cyclic neutropenia is a benign neoplasm associated with clonal proliferation of large granular lymphocytes
Human cyclic neutropenia occurs in children and adults. Adult-onset cyclic neutropenia is an acquired disease characterized by increased numbers of large granular lymphocytes (LGL), in contrast to childhood-onset cyclic neutropenia in which LGL counts are normal. We investigated the clonality of lymphocytes in these two groups of patients by assessing the rearrangement status of the T cell rece...
متن کاملChronic Refractory Uveitis in a Patient with Childhood-Onset Cyclic Neutropenia
We report a rare case of chronic refractory uveitis in a patient with childhood-onset cyclic neutropenia (CN). A 19-year-old woman, who had a history of CN beginning at age 2, presented with bilateral chronic nongranulomatous uveitis, complicated cataract, retinal vasculitis, cystoids macular edema, and vitreous hemorrhage. She had recurrent episodes of oral ulcers, tonsillitis, genital ulcers,...
متن کاملa case report of cyclic neutropenia associated with pyoderma gangrenosum
we present a 24-year-old female referred with non-healing wound of a few days duration on anterior aspect of her right foreleg. biopsy of the wound was reported to be pyoderma gangrenosum on pathologic report. further work up of the patient for high grade fever and occasional leukopenias revealed the diagnosis of cyclic neutropenia. treatment with granulocyte colony-stimulating factor (g-csf) r...
متن کاملSpontaneous regression of a monoclonal proliferation of large granular lymphocytes associated with reversal of anemia and neutropenia.
A 43-year-old male with a phenotypically homogeneous, expanded subset of T cells presented in 1981 with anemia and neutropenia. The surface antigen phenotype of 99% of the peripheral blood lymphocytes was T3+, T8+, T4-, and they were morphologically large granular lymphocytes (LGL). The same cells comprised 37% of the marrow nucleated cells. Eight months after he presented, the peripheral blood...
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ژورنال
عنوان ژورنال: British Journal of Ophthalmology
سال: 1997
ISSN: 0007-1161
DOI: 10.1136/bjo.81.5.415